Objective: To analyze the clinical risk factors for inducing acute suppurative cholangitis (ASC) in patients with bile duct stones.
Methods: Clinical data of 436 cases with bile duct stones from June 1998 to March 2009 in the Second Pepole′s Hospital of Qinzhou City were analysed retrospectively. Patients were divided into two groups: (1) ASC group, 74 cases. (2) Non-ASC group, 362 cases. Single and mutiple factors analysis were adopted to analyze the risk factors,such as age, sex, liver function, number of bile duct stones, stone diameter, site of bile duct obstruction, gallbladder stones, previous cholecystectomy, bile duct diameter, previous cholangitis, previous biliary surgery, diabetes mellitus, cardiovascular disease, and respiratory disease.
Results: There were 74 cases of ASC, accouting for 16.74% of bile duct stone. The univariate analysis showed that age, liver function, site of bile duct obstruction, previous cholangitis, previous biliary surgery and diabetes mellitus were the high risk factors for inducing ACS. Meanwhile, the mutivariate analysis indicated that age, previous choledochotomy and diabetes mellitus were the independent factors for ACS.
Conclusions: Age, previous biliary surgery and diabetes mellitus are the main high risk factors for inducing ACS in patients with bile duct stones. An understanding of the high risk factors for ACS in patients with bile duct stone serves as a guide for better treatment of bile duct stone and preventon of ACS.