Objective：To evaluate the cancer-residual status in the margins following Mammotome biopsy for early-stage breast cancer.
Methods：A total of 283 patients with nonpalpable breast lesions underwent high-frequency ultrasound-guided mammotome biopsy. Among them, the margins status of patients with breast cancer finally diagnosed by mammotome biopsy was evaluated.
Results：In total, 52 breast cancer patients were diagnosed by mammotome biopsy,   included 38 cases of ductal carcinoma in situ(DCIS) and 14 cases of invasive ductal carcinoma. There were 43 cases of negative margins and 9 cases of positive margins.The 9 cases with positive margins underwent lumpectomy for residual carcinoma. Of these 9 cases, 5 cases had negative margins and 4 cases had positive margins after lumpectomy, and the latter 4 cases with positive margins underwent simple mastectomy with a diagnosis of extensive intraductal component(EIC). The diagnosis by Mammotome biopsy was consistent with biopsy in 48 cases.
Conclusions：High-frequency ultrasound-guided Mammotome biopsy is a safe and effective method to diagnose early-stage breast cancer of nonpalpable breast lesions, and could effectively excise the lesions.