Objective：To investigate the diagnosis and treatment methods of ruptured femoral artery psudoaneurysm caused by drug injection.
Methods：A retrospective analysis of the clinical data of 22 cases of ruptured femoral artery false psudoaneurysm caused by drug injection and treated from March 2003 to February 2009 was conducted. 
Results：All patients underwent operation. After excision of the aneurysm and debridement, 8 cases had repair of the femoral artery rupture, 4 cases were additionally treated by proximal and distal ligation of femoral artery, and 10 had proximal and distal ligation of the ruptured artary and prosthetic interposition graft between external iliac and femoral arteries. The  lower extremities of all the patients were successfully saved. During 6 months to 7 years follow up, 1 patient occurred graft infection, 1 had vassel anastomrostic bleeding, both were cured by reoperation; and 2 cases of argery ligation had mild intermittent claudication.
Conclusions：Excision of pseudoaneurysm, local debridement and repair of the rupture is the simplest and safest method to treat rupture of femoral artery pseudoaneurysm. Prosthetic graft is an effective operation to maximally save the blood supply for the affected extremity. Ligation of the femoral artery is also an effective and safe method to cure the disease in selected patients.