Objective：To study the perioperative changes of blood lipids in hepatocellular carcinoma（HCC） patients undergoing hepatectomy and their relationship with prealbumin and aminopherase.
Methods：Triglyceride, cholesterol, prealbumin and transaminase levels were detected in 126 HCC patients undergoing hepatectomy before operation and day 1, 3 and 7 after operation.
Results：Preoperatively, compared to the control group, HCC patients had significantly lower level of cholesterol (P<0.01). On day 1, 3 and 7 after operation, the level of triglyceride and cholesterol reduced significantly compared with preoperative levels. Changes of cholesterol level and ALT were reversely related (r=-0.231, P<0.05), and the change of cholestrol level had no relevant relationship with prealbumin（r=0.082, P>0.05）.
Conclusions：HCC patients may have metabolic disorder of blood lipids; the postoperatively low level of blood lipids may be related to surgical stress and damage of liver function.