Objective:To explore the expression of AnnexinⅠ in pancreatic cancer and its clinical significance.
Methods: Immunohistochemical method and the Western blot method were used to examine the expression of AnnexinⅠ in pancreatic cancer tissues, tumoral adjacent tissues, and normal pancreatic tissues obtained during operation from 40 pancreatic carcinoma patients and 20 patients with normal pancreas. The relationships with pathological grade, clinical stage and metastasis of pancreatic cancer were statistically analyzed.
Results:The percentage of positive cells that expressed AnnexinⅠ protein in human pancreatic tissues, tumor  adjacent tissues and normal tissues was 72.5%, 37.5% and 20.0%, respectively, with the protein expression level of AnnexinⅠ showing gradual decline from cancer to normal tissue (P＜005). The highly expressed AnnexinⅠ correlated significantly with the degree of tumor differentiation, advanced TNM stage and lymph node metastasis. Similar results were obtained by Western blot test.
Conclusions:AnnexinⅠ has high expression in pancreatic cancer tissues. AnnexinⅠ expression has a close relationship with pathological grades of pancreatic cancer, suggesting that AnnexinⅠ might play an important role in the development and progression of pancreatic cancer through immunologic mechanism.