Objective:To study the etiology, prevention and treatment of post-cholecystectomy syndrome.
Methods:A total of 253 patients with cholelithiasis treated in our hospital between 1998 and 2008 were surveyed. Of these patients, 133 underwent endoscopic minimally invasive gallbladder-preserving cholecystolithotomy, 25 patients laparoscopic cholecystectomy and 95 patients open cholecystectomy.
Results:Among the 120 patients who underwent cholecystectomy, non-organic post-cholecystectomy syndrome occurred in 11 patients(9.2%), and non-organic post-gallbladder-preserving operation syndrome occurred in 11 of 133 cases (8.3%). There was no significant differences in the rate of non-organic postoperative syndrome between cholecystectomy group and endoscopic minimally invasive gallbladder-preserving cholecystolithotomy group.
Conclusions:Postcholecystectomy syndrome is not related to whethar or not cholecystectomy is perforned.  The decreasing of biliary compliance caused by bile duct pressure changes and long-term bland diet may be the etiology of postoperative syndrome.  Gallbladder-preservation is important for buffering and maintaining normal bile duct pressure. Recovery training of biliary function can decrease the rate of postoperative syndrome.