Objective:To explore the methods of surgical treatment of huge duodenal diverticulum. Methods:The clinical data of six cases of huge duodenal diverticulum treated in our hospital and the Surgical Hospital, Heidelberg University during the period of Sep.2008 to Oct.2010 were retrospectively analysed. Results:Of them, four cases underwent duodenal diverticulectomy and transgastric duodenostomy, other two cases were operated by Billroth-II gastrectomy and cholangio-enterostomy. After operation, no complications, such as pancreatic fistula, biliary fistula, duodenal fistula or acute pancreatitis,occured. The patients were folloed-up three months to one and a half years after the operation, and none of the patients experienced any discomfort in the right upper abdomen or any other complications. Conclusions:It is reasonable to adopt duodenal diverticulectomy and transgastric duodenostomy for huge duodenal diverticula. This operation is safe and the complications are few.