Objective: To study the dignosis and treatment of isolated cecal necrosis. Methods:The aetiology, diagnosis, treatment and outcome of 12 cases of isolated cecal necrosis were analysed retrospecively. Results:Among the 12 cases, 7 were male and 5 female. The average age was 68.1 years 9 cases had diabetes, 7 had coronary heart disease and 11 had hypertension. The clinical manifestations were shifting or persistent right lower abdominal pain and right lower abdominal peritoneal irritation. Eight cases were diagnosed preoperatively as acute appendicitis and 4 cases as abdominal pain of unknown origin.All of them underwent operation and their cecum was found to be partially gangrenous. The diameter of the lesion was 2-4 cm(average 2.7 cm). Ileocecal resection was performed in all cases. All the patients were discharged without any complications except 2 cases had incisional wound infection. During a follow-up of 8-87 months(mean:56.7months)， 7 patients died of myocardial infarction at 10-36months(mean:16.3months) after operation. The other 5 patients were alive. Conclusions:Isolated cecal necrosis is rare and difficult to be diagnosed. Diagnostic laparoscopy could be applied, if necessary to clinch the diagnosis. Whether surgical treatment is needed or not, depends on the individual case. The pathogenesis of this disease may be related with myocardial infarction.