Objective：To study the expression and clinicopathological relevance of chemokine receptor 5 (CCR5) in breast cancer tissues and metastatic axillary lymph nodes. Methods：The paraffin specimens of 72 cases of invasive ductal carcinoma (IDC) along with the invoved axillary lymph nodes, 50 cases of breast fibroadenoma and 40 cases of normal mammary gland were collected. The expression of CCR5 protein in those specimens was detected by immunohistochemical staining. Meanwhile, the expressions of C-erbB-2, P53, Ki-67, ER and PR in the specimens of IDC were also measured with immunohistochemical method. Finally, the immunohistochemical results were statistically analyzed with regard to correlations with their clinicopathological data. Results：(1) The positive expression of CCR5 in IDC was 84.72% (61/72)， breast fibroadenoma tissue presented low positive expression of CCR5 (14%, 7/50)， and no CCR5 expression was found in normal breast tissue. (2) The expression of CCR5 in IDC had a positive correlation with lymph node metastasis (χ2=4.982, P=0.026, r=0.305). (3) Of the 50 cases with axillary lymph node metastasis, CCR5 was simultaneously expressed both in primary cancer and its invoved axillary lymph nodes in 39 cases, which showed a high homology. (4) There was a low positive correlation between CCR5 and breast cancer oncogene C-erbB-2 (P<0.05, r=0.291). (5) CCR5 showed no relationship with age of onset, maximum diameter of tumor, mensis status or clinical stage (P>0.05). (6) CCR5 had no direct correlation with the expression of p53, Ki-67, ER, PR (P>0.05). Conclusions：CCR5 plays an important role in occurrence and development as well as axillary lymph node metastasis of breast cancer. CCR5 may be one of the indirect indicators to predict axillary lymph node metastasis and prognosis of breast cancer.