Objective: To investigate the feasibility and efficacy of combination of gastric or colonic cancer resection with pancreaticoduodenectomy (en bloc PD) for locally advanced gastric or colonic cancer. Methods: The clinical data of 15 patients with locally advanced gastric or colonic carcinoma with pancreatic head and duodenum involvement undergoing en bloc PD between May 2004 to December 2010 were retrospectively analyzed, and included 12 cases of primary or recurrent gastric cancer and 3 cases of colonic cancer. Results: The median operating time was 6 h (4-12 h) and the median length of postoperative hospital stay was 21 d (7-63 d). The incidence rate of complications was 46.7% (7/15), reoperation rate was 6.7% (1/15) and mortality was 6.7% (1/15). The median survival time was 23 months and the 1-, 2- and 3-year cumulative survival rate was 62.2%, 44.4% and 22.2%, respectively. Conclusions: En bloc PD could be considered as one of the therapeutic options for locally advanced gastric or colonic cancer with pancreaticoduodenal involvement, and it may prolong the survival time of some these patients.