Expression of glypican-3 in breast cancer and its significance
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R 737.9

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    Abstract:

    Objective: To investigate glypican-3 expression in breast cancer tissue and its correlation with clinicopathological factors of breast cancer.
    Methods: The glypican-3 gene expressions in the breast cancer tissues and adjacent normal tissues from 52 patients were detected with RT-PCR method, and then their positive rates were determined. The glypican-3 protein expressions in the breast cancer tissues and adjacent normal tissues were also detected by Western blot technique.
    Results: The expression rate of glypican-3 mRNA of the breast cancer tissue was significantly lower than that of the adjacent normal tissue (P<0.05), and of the patients with lymph node metastasis was significantly lower than that of the patients without lymph node involvement (P<0.05). Furthermore, the less differentiated the cancer, the lower the expression rate of glypican-3 mRNA (P<0.05), but the glypican-3 gene expression was unrelated to the age and tumor size of patients (P>0.05). The expression level of glypican-3 protein of the breast cancer tissue was significantly lower than that of the adjacent normal tissue (P<0.05), and of the patients with lymph node metastasis was significantly lower than that of the patients without lymph node involvement (P<0.05). A poorer differentiation of the cancer tissue was correlated with lower expression level of glypican-3 protein (P<0.05).
    Conclusions: The low expression state of glypican-3 may probably be associated with the occurrence and development, and as well as invasion or metastasis of breast cancer.

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ZHOU Dong| XU Liang| LI Jianguo. Expression of glypican-3 in breast cancer and its significance[J]. Chin J Gen Surg,2011,20(11):1216-1220.
DOI:10.7659/j. issn.1005-6947.2011.11.017

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History
  • Received:August 30,2011
  • Revised:October 02,2011
  • Adopted:
  • Online: November 15,2011
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