Objective: To investigate the feasibility and efficacy of endovascular treatment of TASC II-C/D femoropopliteal arteriosclerosis obliterans. Methods: The clinical data of 74 patients with TASC II-C/D femoropopliteal arteriosclerosis obliterans undergoing endovascular treatment from September 2008 to February 2011 were retrospectively analyzed and the patients were followed up to ascertain their outcome. Results: The technical success rate was 92.6% and no severe perioperative complications occurred. The ankle-brachial index (ABI) and toe-brachial index (TBI) were both significantly increased compared with those before the procedure (both P＜0.01). Sixty-nine patients were followed up for two to 24 months after endovascular treatment. The patency rate of the affected limb at 6, 12 and 24 months after treatment was 81%, 63% and 51%, and the symptom relief rate was 92%, 83% and 76%, respectively. Conclusions: Endovascular treatment of TASC II-C/D femoropopliteal arteriosclerosis obliterans has satisfactory short-term efficacy, and it can be used as the first choice for elderly patients or those with poor tolerance to surgery. Its long-term results require further observation.