Objective: To investigate the application value of small covered self-expanding stent in treatment of arterial disease. Methods: The clinical data of 30 patients undergoing implantation of small covered self-expanding stent for artery related disease from October 2007 to May 2011 were retrospectively analyzed. Results: Of the patients, there were 5 cases of arterial bleeding, whose lesions were located on common iliac artery (2 cases), carotid artery (2 cases) and left subclavian artery (1 case) respectively, 2 cases of traumatic arteriovenous fistula of the lower limb, 3 cases of congenital arteriovenous fistula, 2 cases of subclavian artery aneurysm, 5 cases of acute aortic syndrome, 4 cases of chronic aortic dissection with a second tear and 9 cases of aortoiliac occlusive disease. Stents were successfully implanted in all patients and the primary lesions of the patients were substantially resolved. The follow-up period ranged from 3 to 36 months, with an average of 16 months. In the 2 patiants with carotid artery hemorrhage, stent occlusion occurred 12 months after operation, but no nervous system problems were noted. The stents in the remaining patients were all patent as shown by Doppler ultrasound and contrast-enhanced CT examination. Conclusion: Small covered self-expanding stent implantation for arterial disease is a fast performed operation, with minimal invasion and demonstrable efficacy, and is irreplaceable in some special cases.