Objective: To investigate the efficacy of selective hemihepatic vascular occlusion in hepatectomy for cavernous hemangioma. Methods: The clinical data of 104 patients with hepatic cavernous hemangioma undergoing surgical resection from January 2006 to January 2011 were retrospectively analyzed. Of the patients, selective hemihepatic vascular occlusion was performed in 26 cases (group A), and the Pringle maneuver was performed in 78 patients (group B). The influence of the two approaches on the parameters that included intraoperative conditions, postoperative liver function and incidence of complications were compared and analyzed. Results: Operations were successfully performed in all the 104 patients. There were no statistical differences in intraoperative bleeding, blood transfusion volume, hepatic inflow occlusion time, blood oxygen saturation, time to intestinal function recovery and incidence of complication between the two groups (all P>0.05), but the alterations of peripheral blood pressure and arterial pulse in group B were more evident than those in group A (both P<0.01). The postoperative changes of liver function parameters such as ALT, AST, ALB and TBIL in group B were more favorable than those in group A, and all the differences had statistical significance (P<0.05 or P<0.01). Conclusion: Using selective hemihepatic vascular occlusion in hepatic resection of cavernous hemangiom can effectively reduce the impact of hepatic blood flow occlusion on systemic hemodynamics, alleviate hepatic ischemia–reperfusion injury, and thereby facilitate recovery of postoperative liver function.