Objective: To investigate the morbidity and clinical features of cholelithiasis in recent years in Tangshan region. Methods: The clinical data of 6 417 patients with cholelithiasis confirmed by surgery between June 2005 and June 2011 were retrospectively analyzed. Results: The total number of cholelithiasis patients showed an increasing trend over the years (P<0.01), in which cholecystolithiasis accounted for 85.29%. For the entire group of cholelithiasis patients, the male to female ratio was 1:1.65, and cholecystolithiasis was predominant in both sexes. The peak age in the cases of gallbladder stones was 41–50 years, and in those of extrahepatic as well as those of intrahepatic bile duct stones it was 51–60 years. As for the occupational composition ratio, farmers (34.19%) and office staffs (36.82%) were the main sufferers of gallbladder stones at the time of this survey, and farmers accouted for the majority of intrahepatic bile duct stones (80.00%). The proportion of farmers in the cholecystolithiasis population showed a rising tendency (P<0.01). Conclusion: Cholecystolithiasis is the most important type of cholelithiasis in Tangshan, and farmer and office staffs are the main sufferers of this disease.