Objective: To investigate the common difficulties and solutions in transumbilical single-port laparoscopic appendectomy. Methods: The clinical data of 86 patients with appendicitis undergoing transumbilical single-port laparoscopic treatment in Leliu Hospital from June 2009 to February 2012 were retrospectively analyzed. Results: The difficulties encountered during operation included 15 cases of intra-abdominal abscess, 6 cases with difficulties in appendix exposure, 5 cases with difficulties in appendiceal stump treatment and 3 cases of abdominal adhesions. Single-port laparoscopic appendectomy was successfully performed in 78 cases, 8 cases were converted to conventional laparoscopic operation and there was no open conversion. The average operative time was (41.39±13.76) min and the length of postoperative hospital stay was (4.82±2.16) d. No complications such as postoperative hemorrhage and wound infection occurred in any of the patients. Conclusion: Transumbilical single-port laparoscopic appendectomy is safe and feasible. The appropriate methods and techniques should be taken according to the appendiceal lesions when it is difficult to perform single-port laparoscopic appendectomy, so as to effectively prevent complications.