Objective: To investigate the treatment strategies for patients with operable breast cancer of different subtypes. Methods: The clinical data of 80 patients with operable breast cancer admitted from March 2007 to December 2009 were retrospectively analyzed. Results: Different surgical procedures were done to the patients according to their tumor size, depth of invasion and lymphatic metastasis. Postoperatively, the patients underwent individualized combination therapy depending on their tumor molecular subtypes, namely luminal A, luminal B, HER2-enriched and basal-like, determined by immunohistological method. Satisfactory therapeutic results were obtained in 88.8% of the patients. Local recurrence occurred in 3 patients and distant metastasis occurred in 6 patients, respectively. The patients with luminal A or B breast cancer had a higher disease-free survival rate, while those with Her-2-enriched and basal-like breast cancer showed a poor prognosis as evidenced by increased local recurrence and distant metastasis. Conclusion: The postoperative individualized comprehensive therapy depending on different molecular subtypes is an effective treatment strategy for the operable breast cancer patients.