Objective: To assess the clinical value of using the concept of precise liver surgery in the treatment of liver hemangioma. Methods: The clinical data of 52 patients with liver hemangioma undergoing hepatectomy during the past three and a half years were retrospectively analyzed. Of the patients, 23 cases underwent precise hepatectomy, and another 29 cases underwent traditional hepatectomy. Results: The operations were performed successfully in all patients. All of them recovered well with no serious complications during operation and the perioperative period, and no death occurred. In precise hepatectomy group, compared with the traditional hepatectomy group, there was prolonged operative time [(128.0±25.7) min vs. (100.9±20.4) min] (P<0.05), and similar intraoperative blood loss and ratio of blood transfusion requirement (both P>0.05), but reduced length of postoperative hospital stay [(7.0±1.5) d vs. (8.6±1.5) d] (P<0.05), and postoperative peak levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) [(277.5±189.3) U/L vs. (960.0±635.0) U/L; (254.2±191.4) U/L vs. (838.5±677.1) U/L], as well as decreased postoperative complications (8.7% vs. 31.0%) (all P<0.05). Conclusion: Precise liver surgery is safe and effective for liver hemangioma with significant advantages versus traditional hepatectomy.