Objective: To investigate the clinical applicability of modified end-to-side invaginated pancreaticojejunostomy. Methods: The clinical data of 31 patients undergoing pancreatoduodenectomy (PD) from February 2004 to November 2012 were reviewed. Of the 31 patients, 19 were males and 12 were females with average age of 58 (16–76) years; 16 cases had pancreatic head cancer, 5 had ampullary cancer, 8 had inferior common bile duct cancer, and 2 had duodenal tumors. PD and modified end-to-side invaginated pancreaticojejunostomy were performed in all patients. The postoperative recovery and incidence of complications after reconstruction of gastrointestinal tract of the patients were analyzed. Results: Of the entire group, the operative time was 160–260 min, intraoperative blood loss was 100–500 mL, and the overall incidence of complications was 12.9%, including ascites and pancreatic fistula in 2 cases each, which were resolved by conservative therapy. There was no surgical death, and all patients were cured and discharged from the hospital. Conclusion: The modified end-to-side invagination technique for post-PD pancreaticojejunostomy has the advantages of easier performance, shorter operative time and less postoperative complications, so it is an effective improvement of pancreato-enteric anastomosis.