Objective: To investigate the efficacy of gastrectomy plus pancreaticoduodenectomy (PD) in treatment of locally advanced gastric cancer. Methods: The clinical data of 11 patients with stomach cancer undergoing gastrectomy plus PD due to pancreatic head or duodenal involvement during May 2005 to Jun 2012 were retrospectively analyzed. Results: Of the patients, 6 cases underwent distal subtotal gastrectomy with simultaneous PD, and 5 cases underwent distal subtotal gastrectomy plus PD and right hemicolectomy. No death occurred in the whole group of patients, and postoperative complications occurred in 4 cases, of whom, one case had biliary fistula, one had pancreatic fistula, one had intra-abdominal infection and one had wound infection. The 1-, 3- and 5-year survival rates were 68.2%, 34.1% and 22.7%, respectively. Conclusion: For stomach cancer patients with pancreaticoduodenal involvement, gastrectomy plus PD is an effective procedure as long as an R0 resection can be achieved.