Objective: To evaluate the outcomes of minimally invasive endovascular treatment for post-thrombotic syndrome (PTS) following deep vein thrombosis (DVT) of the lower extremity. Methods: The clinical data of 262 PTS patients (275 limbs) after lower extremity DVT treated within 7 years were retrospectively analyzed. All patients underwent minimally invasive endovascular treatment under local anesthesia. In these patients, 74 limbs underwent percutaneous transluminal angioplasty (PTA), and 201 limbs received PTA plus stent placement. Results: Two-hundred and sixty-eight legs (97.5%) were successfully treated, with complete recanalization of the occluded vessel and restoration of the normal blood flow. Seven legs (failure to traverse the left common iliac vein segment) were partially recanalized via ascending lumbar vein or collateral veins. Two-hundred and forty patients (91.6%), 253 legs were followed up for 8 to 96 months with mean period of (48.3±20.2) months, and 94 limbs (37.2%) achieved complete relief, 152 limbs (60.0%) obtained significant relief, and 7 limbs (2.8%) had minor relief. Conclusion: Endovascular management is an effective treatment for PTS following lower extremity DVT with minimal invasiveness and fast recivery.