Objective: To investigate the proper options for different hepatic blood flow occlusion methods during liver cancer resection. Methods: The data of 124 patients undergoing liver cancer resection were respectively analyzed. According to the method of blood flow occlusion, patients were divided into group A (51 cases undergoing total hepatic inflow occlusion), group B (38 cases undergoing selective inflow occlusion), group C (24 cases undergoing selective inflow and outflow occlusion) and group D (11 cases undergoing complete hemihepatic vascular occlusion). The operative time, duration of hepatic ischemia, intraoperative blood loss, blood infusion requirement, postoperative liver function recovery and incidence of postoperative complications as well as mortality among the 4 groups were compared. Results: The general conditions among groups showed no significant differences before operation (all P>0.05). There were no significant differences among the 4 groups with regard to the duration of hepatic ischemia, incidence of postoperative complications and mortality (all P>0.05). The operative time in both group C and group D were significantly prolonged versus group A (both P<0.05), but their intraoperative blood loss and infusion requirements were less than those in group A or group B (all P<0.05). The postoperative levels of alanine aminotransferase (ALT) and total bilirubin (TBIL) in group A were increased relatively higher than those of other groups, as the former showed significant difference versus all other groups, and the latter versus group B reached a statistical significance (all P<0.05). Conclusion: Proper selection of method of hepatic blood flow occlusion is based on overall consideration of several factors such as the size and location of the tumor, preoperative liver function, underlying liver disease, and function of cardio-cerebral vascular system. It also, greatly depends on the surgeon’s judgment and experience.