Objective: To investigate the feasibility and safety of liver resection with liver hanging maneuver for tumors adjacent to the second porta hepatis. Methods: The clinical data of 7 patients with liver neoplasms near the second porta hepatis admitted from August 2011 to August 2012 were analyzed retrospectively. Results: The liver hanging tape was positioned as planned and operation was successfully performed in all the 7 patients. Of the patients, 2 cases underwent right hemihepatectomy, one case underwent right hemihepatectomy plus perirenal fatty capsule resection, one case underwent right hemihepatectomy plus removeal of two haemangiomas in the left medial and lateral lobes, one case underwent right hemihepatectomy plus partial segment IV resection, one case underwent left hemihepatectomy plus segment VIII resection and right diaphragmatic peritoneal stripping, and 1 case underwent anatomical segment VI and VII resection. Inadvertent inferior vena cava injuries during parenchymal transection did not occur in any of the cases, and one case underwent fascial repair of the right diaphragm. The median operative time was 375 (295–460) min, median intraoperative blood loss was 2 000 (750–8 000) mL, and median blood transfusion requirement was 1 000 (0–4 000) mL. Two patients developed postoperative pleural effusion that resolved by puncture and aspiration. No bile leakage or abdominal infection occurred; all patients were cured and discharged from hospital, and the average length of postoperative hospital stay was 20 d. Patients were followed up for 1 to 12 months, and one case developed local recurrence of hepatocellular carcinoma. Conclusion: Hepatectomy using liver hanging maneuver for tumors adjacent to the second porta hepatis is safe and feasible.