Objective: To investigate the methods and efficacy of laparoscopic Roux-en-Y diversion for intractable gastroesophageal reflux and respiratory symptoms following gastroesophageal surgery. Methods: The data from 5 patients with this disorder, which included the surgical history, clinical manifestations and Roux-en-Y diversion procedures as well as the results during the follow-up period of 12 to 22 months, were studied. Results: All the patients underwent a 40-cm jejunal Roux-en-Y diversion, and no operative death or postoperative complications occurred. The reflux and respiratory symptoms were completely relieved in 4 patients, and were significantly improved in one patient. Use of antireflux drugs was discontinued in all patients. Conclusion: Laparoscopic Roux-en-Y diversion can effectively correct the intractable gastroesophageal reflux and associated digestive and respiratory symptoms following esophagectomy or subtotal gastrectomy.