Objective: To investigate the diagnosis, treatment and prognosis of glucagonoma with liver metastasis. Methods: The two hospitalization records of one glucagonoma patient with liver metastasis were reviewed. Based on the patient’s surgical history of distal pancreatectomy plus splenectomy, the treatment modality and results of this condition were analyzed. Results: After confirmation by laboratory and imaging examinations, this case of metastatic glucagonoma to the liver underwent right posterior lobectomy and regional resection of the tumor in the left lobe plus cholecystectomy by using ultrasound knife, and was discharged after improvement. The patient recovered well during the one-month follow-up period. Conclusion: Liver metastasis may occur in glucagonoma after surgery. Surgical removal is the effective treatment option for this condition with better prognosis. Liver transplantation may be considered when necessary.