Objective: To investigate the clinicopathologic profile and distributional features of molecular subtypes of breast cancer in Hunan Province, and their differences from other geographic regions in China and other countries. Methods: The clinicopathologic data of 2 324 breast cancer female patients admitted in Xiangya hospital from January 2002 to September 2012 were reviewed, and the features of molecular subtypes divided by the status of estrogen receptor (ER), progestrone receptor (PR), Ki-67, and epidermal growth factor receptor (Her-2) were analyzed. Results: Of the breast cancer patients in Hunan, the average age was 47.57 years, the proportion of premenopausal cases (64.5%) was higher than that of postmenopausal cases (35.5%), and the cases with stage II cancer accounted for the major part; the differences in molecular subtype distribution were all statistically different from those of other geographic regions in China and other countries (all P<0.05); the luminal A subtype accounted for 59.6%, which was higher than that of patients in Shanghai (52.8%), Guangdong (31.1%), and among African-Americans (55.5%), but lower than that of Poles (73.0%) and Americans (66.1%), and the proportion of Her-2 subtype (5.6%) was lower than that in all other populations while the proportion of triple negative (22.0%) was higher than of the majority of other populations; the molecular subtype distribution had statistical difference between or among the groups divided by age, tumor stage, menstrual status and whether or not neoadjuvant chemotherapy was administered (all P<0.05). Conclusion: Among women in China Hunan province, the average age of onset of breast cancer is relatively early, and most of the patients are premenopausal women with luminal A as the predominant subtype; the molecular subtype distribution is related to age, tumor stage, menstrual status and neoadjuvant chemotherapy.