Objective: To assess the efficacy and short- and mid-term results of endovascular surgery and hybrid surgical procedures in treatment of complex aortic pathology. Methods: The clinical data of 53 patients with complex aortic diseases admitted from April 2003 to December 2012 were retrospectively analyzed. Of the patients, 39 cases were male and 14 cases were female, and their ages ranged from 31 to 82, with an average age of 55 years; 35 had aortic dissection, 2 cases had aortic arch aneurysm, and 16 cases had abdominal aortic aneurysm; 5 cases were complicated with iliac artery aneurysms. Different endovascular techniques, and/or hybrid procedures were performed in these patients. Results: The technical success rate was 100% for the entire group of patients. Type I endoleak occurred in 8 patients immediately after stent-graft placement, which in 2 cases disappeared after a proximal Cuff placement, and in the remaining cases required no special treatment. Follow-up was conducted for 1 month to 72 months, with an average of 20.2 months, and no stent-graft migration or organ ischemia was noted. In the follow-up patients, no type I endoleak occurred but type II endoleak was found in 2 cases, which resolved without treatment; no patient had paraplegia, but one elderly patient with abdominal aortic aneurysm died one month after operation due to asphyxia resulting from viscous sputum. Conclusion: Endovascular surgery and hybrid procedures have demonstrable short- and mid-term efficacy in treatment of complex aortic diseases. Their long term efficacy, however, needs further evaluation.