Objective: To evaluate the influence of Chen’s simplified technique of total hepatic vascular occlusion (Pringle’s maneuver plus infrahepatic vena cava occlusion) on the degree of bleeding from the cut surface of the liver. Methods: The clinical data of 280 patients undergoing liver resection from January 2010 to January 2013 were reviewed. The severity of bleeding from the cut surface of the liver was classified as grade 0 to grade IV, according to the clearness of operative field. Changes of the degree of bleeding of the liver section surface were recorded after performing the first hepatic portal occlusion (Pringle maneuver) and Chen’s occlusion. Results: The operative field was excellent in 98 (98/280, 35%) cases of the 280 patients after Pringle’s maneuver, which was classified as grade 0 in 45 cases and grade I in 53 cases. Of the remaining 182 patients undergoing additional infrahepatic vena cava occlusion, satisfactory operative field was achieved in 115 (115/280, 41.1%) cases, which was classified as grade 0 in 55 cases and grade I in 60 cases; the degree of bleeding from the cut surface was lessened in 47 (47/280, 16.8%) cases, which was classified as grade II in 39 cases and grade III in 8 cases, and showed no obvious improvement in 13 (13/280,4.6%) cases, which was classified as grade II in 10 cases and grade III in 3 cases; 3 (3/280, 1.1%) cases who developed massive hemorrhage due to the injury of the trunk of the hepatic veins were classified as grade IV; the procedure was abandoned in 4 (4/280, 1.4%) cases because the blood pressure dropped to below 60 mmHg (1 mmHg=0.133 kPa). Conclusion: Chen’s simplified total hepatic vascular occlusion can safely and effectively control bleeding from the cut surface during liver transection, is easy to perform, and may facilitate a bloodless and precise liver resection.