Objective: To analyze the value of duodenum-preserving pancreatic head resection (DPPHR) for benign tumors of the pancreatic head. Methods: The clinical data of two DPPHR cases performed in the First Affiliated Hospital of China Medical University in the year 2011 were presented. Together with the data of 66 DPPHR cases described in 9 literature reports over the recent 10 years in China, the complications and surgical efficacy of all the 68 DPPHR cases were retrospectively analyzed. Results: Of the 68 patients, postoperative complications occurred in 13 cases (19.2%), which comprised pancreatic fistula in 10 cases (14.7%), duodenal fistula in 1 case (1.5%), gastroparesis in 1 case (1.5%), and biliary infection in 1 case (1.5%), and all of them were successfully treated by non-surgical treatment. The length of hospital stay ranged from 11 to 57 d with average of 17 d, and no death occurred during hospitalization. Follow-up data were available in 44 cases with the follow-up period of 3 months to 6 years, and no recurrence occurred in any of them. Conclusion: DPPHR is a safe and effective treatment method for benign tumors in the head of the pancreas.