Objective: To investigate c-Met expression in colorectal carcinoma tissue either with or without liver metastasis and its clinical significance. Methods: The c-Met mRNA and protein expressions in 48 specimens of primary colorectal cancer tissues with liver metastasis and 48 specimens of primary colorectal cancer tissues without liver metastasis were determined by real-time PCR method and Western blot analysis, respectively. The relations of c-Met expression with some clinicopathologic profiles were analyzed. Results: Both c-Met mRNA and protein expressions in primary colorectal cancer tissues with liver metastasis were higher than those in primary colorectal cancer tissues without liver metastasis, and the differences had statistical significance (both P<0.05). Both the c-Met mRNA and protein expression levels were significantly related to clinical stage and lymph node metastasis (both P<0.05), but irrelevant to sex, age, degree of differentiation and tumor location (all P>0.05). Conclusion: High c-Met expression is associated with colorectal cancer liver metastasis, and c-Met detection may have an important value for predicting colorectal cancer liver metastasis.