Lymphangiogenesis and mechanisms of lymphatic metastasis have become the research focus of tumor metastasis with the findings of the specific markers of lymphatic endothelium. Hematogenous metastasis has been thought previously to be the common route for colorectal cancer liver metastasis, but some recent research suggests that lymphangiogenesis and lymph node metastasis play an equally pivotal role in colorectal cancer liver metastasis. In this paper, the authors address the mechanisms of action of lymphangiogenesis and lymphatic endothelial-specific markers in colorectal cancer liver metastasis.