Objective: To investigate the influence of perioperative level of high-sensitive C-reactive protein (hs-CRP) and interleukin 6 (IL-6) on restenosis following femoropopliteal stenting. Methods: Forty-seven patients with femoropopliteal arterial occlusive disease undergoing stent implantation were selected, and their serum levels of hs-CRP and IL-6 on 24 h before and 3 d after operation were determined. Patients were followed-up for 6 months, and ultrasonography was used to detect intra-stent stenosis. The relations of hs-CRP and IL-6 level as well as the preoperative blood glucose concentration, lipid profile and degree of disease with postoperative restenosis were analyzed. Results: All the 47 patients were successfully managed with femoropopliteal stenting, and restenosis occurred in 13 cases during the postoperative follow-up period of 6 months. The levels of hs-CRP and IL-6 at 24 h before and 3 d after operation in restenosis group were all significantly higher than those in non-restenosis group (all P<0.05), and in both the restenosis group and non-restenosis group, the postoperative hs-CRP and IL-6 levels were increased compared with the levels before operation, but the differences in their increasing degrees between the two groups showed no statistical significance (both P>0.05). In addition, the ratio of patients with diabetes mellitus in restenosis group was higher than that in non-restenosis group (P<0.05), and the higher the preoperative TASC II grade was, the more frequent was the occurrence of postoperative restenosis (χ2=7.245, P=0.027). Conclusion: Increased preoperative levels of hs-CRP and IL-6 may increase the risk of restenosis after femoropopliteal stenting, and moreover, restenosis is also closely associated with diabetes mellitus and preoperative severity of the femoropopliteal arterial lesion.