Objective: To assess the efficacy of double intervention approach in treatment of lower extremity deep vein thrombosis (DVT) complicated with acute pulmonary embolism (PE). Methods: The clinical data of 21 patients with lower extremity DVT and secondary acute PE, who underwent inferior vena cava filter placement with pulmonary artery catheter-directed fragmentation and thrombolysis, and in combination with catheter-directed thrombolysis of the affected lower extremity deep vein from January 2010 to May 2013, were retrospectively analyzed. PE was located in the main trunk of pulmonary artery in 2 cases, in the left pulmonary artery in 8 cases, in the right pulmonary artery in 6 cases, and in the lobar pulmonary artery in 5 cases. Results: The double intervention treatment was completed in all the 21 patients for dealing with their pulmonary arteries and lower extremity deep veins. Intraoperative immediate angiography showed the main trunk of pulmonary artery in the 2 cases was fully opened, and left or right pulmonary arteries were fully opened in 8 cases and largely opened in 6 cases, and the lobar pulmonary arteries in 5 cases were partially opened. Pulmonary arterial pressure was decreased from (52±7) mmHg to (27±4) mmHg, and PaO2 was increased from (62±6) mmHg to (82±6) mmHg (both P<0.01). Vascular doppler ultrasound examination showed that all the clots in the affected limbs were dissolved in varying degrees, with a partial or complete restoration of blood flow. The circumference differences 15 cm above and below the knee joint between the healthy and affected limb decreased from (9.0±4.0) cm and (5.0±2.0) cm to (2.3±0.9) and (1.0±0.7) cm, respectively (both P<0.01). Conclusion: For patients with lower extremity DVT and secondary acute PE, the double intervention approach can quickly restore pulmonary flow, correct hypoxemia, and improve the general condition of these patients, as well as dissolve the deep vein thrombus, improve circulation and reduce symptoms in the affected limb, and reduce the sequelae of DVT.