Objective: To investigate the feasibility of using idiopathic deep venous thrombosis (IDVT) of the lower extremity as a model disease for research into the pathogenesis and genetic factors of lower extremity deep venous thrombosis (DVT). Methods: IDVT patients and healthy subjects undergoing health maintenance examination were randomly selected as case group and control group, with 120 cases in each group. The demographical data and parameters of hemodynamics, blood routine, blood biochemistry and clotting function between the two groups were compared. Results: The difference in age and gender composition had no statistical significance between the two groups (both P>0.05). In case group compared with control group, the flow velocity in the femoral and popliteal vein was decreased, and the inner diameter of the femoral and popliteal vein was increased; the red blood cell count and hemoglobin content were decreased and the white blood cell and blood platelet count were increased; the albumin level was decreased and aspartate aminotransferase and creatinine level were increased; the erythrocyte sedimentation rate, prothrombin and fibrinogen level and activated partial thromboplastin time were increased and thrombin time was decreased, and all the differences had statistical significance (all P<0.05). Conclusion: Because of few confounding factors and better equilibrium, lower extremity IDVT is an ideal model disease for clinical and genetic research of lower extremity DVT.