Angiosome is an anatomic unit of tissue, which is consisted of skin, subcutaneous tissue, fascia, muscle and bone, as well as the source artery for its blood supply and its specific drainage veins. According to the angiosome concept, revascularization of the source artery of the below-the-knee (BTK) lesion might result in better wound healing and limb salvage rate in patients with critical limb ischemia (CLI) undergoing either bypass or endovascular operation. In this paper, the authors address the angiosome concept and its role in revascularization strategy making for CLI patients with BTK disease.