The liver regeneration is a complex but precise regulative process involving multiple factors and steps, where the oxidative stress plays an important role. In this paper, the authors address the issues that include the definitions related to oxidative stress and liver regeneration, detrimental effect of oxygen stress on the liver, and relationship between oxidative stress and the liver regeneration, as well as the action mechanism of oxidative stress in liver regeneration process and effect of antioxidant on liver regeneration.