Objective: To assess the safety and efficacy of the application of fast-track surgery (FTS) in perioperative management of laparoscopic liver resection. Methods: The randomized controlled trials (RCTs) or clinical controlled trials (CCTs) concerning application of FTS in perioperative management of laparoscopic liver resection were collected by computer-based search of literature published between January 1966 and June 2014 from national and international databases. Meta-analysis was performed by using RevMan 5.2 software. Results: Three RCTs and 2 CCTs were finally included involving 247 patients, of whom 134 cases received FTS treatment (FTS group) and 113 cases received traditional perioperative care (control group). Results of Meta-analysis showed that the length of hospital stay was shortened and incidence of postoperative complications was reduced in FTS group compared with control group (WMD=-2.19, 95% CI=-2.94--1.43, P<0.00001; RR=0.60, 95% CI=0.38-0.92, P=0.02), while no statistical difference was noted in operative time, open conversion rate and hospitalization costs between the two groups (all P>0.05). Conclusion: Application of FTS in perioperative management of laparoscopic hepatectomy can reduce the length of hospital stay and incidence of complications and thereby accelerate postoperative recovery of the patients. However, the above results require further verification by more well-designed RCTs with large sample size and good quality.