Objective: To evaluate the efficacy of radiofrequency ablation (RFA)-assisted hepatectomy in treatment of colorectal cancer liver metastases (CLM). Methods: The clinical data of 17 CLM patients undergoing open RFA-assisted hepatectomy were reviewed. The operative time, intraoperative blood loss, blood transfusion, and incidence of postoperative complications as well as the alterations in liver function and coagulation function of the patients before and after operation were analyzed. Results: Operations in all patients were successfully performed. The operative time was 55-237 min with an average of (93±19) min, and the intraoperative blood loss was 235-650 mL with an average of (280±40) mL. No blood transfusion was required in any of the patients during and after operation, and the abdominal drainage volume was 170-370 mL. Bile leakage occurred in one case (5.9%). The alanine transaminase (ALT) and aspartate aminotransferase (AST) levels of the patients were significantly elevated on postoperative 24 h and 72 h compared with their preoperative levels (all P<0.05), but both returned to their preoperative levels on postoperative 120 h, while the total bilirubin (TBIL) level and prothrombin time (PT) of the patients showed no significant alteration before and after operation (all P>0.05). Conclusion: RFA-assisted hepatectomy is safe and feasible for CLM, and it can also decrease the risk of bleeding.