Liver transplantation, as the only effective treatment for end-stage liver disease, has since been well recognized. However, the availability of liver donors is far not enough to meet the needs at present. Use of liver from elderly donors (≥ 60 years) can partially alleviate the shortage of liver donors, but it remains controversial. In this paper, the authors address the relevant issues from the aspects of changes in liver of the elderly, current research status, and feasibility of liver transplantation with elderly donors.