Objective: To investigate the factors affecting the prognosis of patients with advanced pancreatic cancer after bypass palliation. Methods: The clinical data of 102 patients with advanced pancreatic cancer admitted from May 2005 to June 2013 who underwent palliative bypass surgery were reviewed. The postoperative survival status and prognostic factors were analyzed. Results: The median overall survival (OS) for the entire group of patients was 8.7 months, and the results of survival analysis showed that the median OS in patients with milder pain was higher than in those with severe pain, in ASA I/II patients was higher than in ASA III ones, in patients with normal C-creative protein (CRP) level was higher than in those with high CRP level, and in patients without metastasis was higher than in those with liver/peritoneal metastases, and all the differences had statistical significance (all P<0.05). Univariate analysis showed that the median OS of the patients was associated with the degree of pain, ASA classification, intraoperative blood loss, whether having liver/peritoneal metastases, and levels of CRP, CA19-9 and albumin (ALB) (all P<0.05). Further, multivariate COX regression analysis identified that ASA class III, severe pain, CRP≥5 mg/L and liver/peritoneal metastases were independent risk factors for prognosis of the patients. Conclusion: ASA class III, severe pain, high CRP level and liver/peritoneal metastases are indicators for a poor prognosis in advanced pancreatic cancer patients after palliative surgery.