Objective: To investigate the clinical characteristics, treatment methods and prognosis of postoperative chest wall breast cancer recurrence. Methods: The clinical data of 113 patients with postoperative chest wall breast cancer recurrence treated at the Affiliated Tumor Hospital of Xinjiang Medical University from January 2004 to June 2014 were collected, and the relations of the various factors with survival of the patients were analyzed. Results: Of the patients, the survival time after chest wall breast cancer recurrence was from 5 to 102 months, with a median survival time of 41 months; the 1-, 2- and 5-year survival rate was 100.0%, 85.0%, and 38.0%, respectively. Univariate analysis showed that tumor size, lymph node metastasis, TNM stage, hormone receptor expression, HER-2 receptor expression, postoperative radiation therapy, targeted therapy, endocrinotherapy, time of disease-free survival to chest wall recurrence, and surgical resection and radiotherapy of the recurrent tumor were associated with the survival of the patients after chest wall recurrence (all P<0.05); multivariate analysis identified that TNM stage, hormone receptor expression, HER-2 receptor expression, targeted therapy, time of disease-free survival to chest wall recurrence were independent prognostic factors for the survival of the patients after chest wall recurrence (all P<0.05). Conclusion: Postoperative chest wall breast cancer recurrence has a relatively mild prognosis, and comprehensive treatment may help improve the cure rate.