Objective: To investigate the feasibility and efficacy of endovascular therapy for patients with recurrence of Budd-Chiari syndrome (BCS) after radical surgery. Methods: The clinical data of 15 patients undergoing interventional treatment for BCS recurrence after radical operation were retrospectively analyzed. Results: In the 15 patients, the age ranged from 30 to 68 (average 46.4) years; interventional procedure was performed 18 times (3 and 2 times for one case each), which included balloon angioplasty of inferior vena cava (IVC) in 10 cases, IVC balloon angioplasty after catheter direct thrombolysis in 5 cases, balloon angioplasty of IVC, hepatic vein and accessory hepatic vein in 2 cases, and IVC balloon angioplasty and stent placement in 1 case. No perioperative complication such as pulmonary artery embolism or pericardial tamponade occurred. Fifteen patients were followed up for 12 to 106 (average 41.9) months, during which time, 13 patients showed no signs and symptoms of recurrence, one patient developed hepatic venous occlusion and then underwent hepatic vein angioplasty and stenting in another hospital, and one patient developed IVC re-occlusion and received conservative treatment. Conclusion: For patients with recurrent BCS after radical operation, timely and appropriate interventional therapy is safe and effective and may improve the cumulative patency rate and prognosis.