Objective: To investigate the changing pattern of quality of life in patients with the lower extremity deep vein thrombosis (DVT). Methods: Seventy-four lower extremity DVT patients were selected. Using SF-36 Health Survey Scale, the scores for 8 subscales of health dimensions that included physical functioning (PF), general health (GH), physical role (RP), emotional role (RE), social functioning (SF), bodily pain (BP), vitality (VT) and mental health (MH), were determined and compared in these patients before and at 2 to 26 months after non-surgical treatment. Results: The base-line data of the patients were evenly distributed and comparable at different stages, and the overall Cronbach’s α coefficient for the scale was 0.902. Of the patients, the scores for the 8 dimensions were all significantly higher at different stages after discharge than those at admission (all P<0.05), however, all dimensions reached a plateau at 2 to 8 months respectively, where all the scores for each dimension showed no significant difference (all P>0.05). Compared with the normal values, the scores for RP and PF were slightly decreased, and score for VT was obviously decreased, but those of all the other dimensions were unchanged. Conclusion: After non-surgical treatment, the condition of DVT patients can significantly be recovered, and their quality of life may be improved for a long period of time.