Objective: To investigate the influence of invaginated stripping of great saphenous vein on perforator reflux. Methods: Thirty-six patients (39 affected legs) with varicose vein of lower limbs associated with perforator vein reflux admitted from March 2010 to March 2012 were selected to undergo invaginated stripping of great saphenous vein. After operation, the symptomatic improvement was evaluated by using venous clinic severity scoring (VCSS) and the condition of perforator vein reflux was observed by color duplex ultrasound. Results: Follow-up was obtained in all patients at one year after operation. The score of VCSS was 1.25±1.48 before operation, which was 5.12±1.36 one year after operation, and the difference achieved statistical significance (P<0.05). A total of 143 refluxing perforator veins was detected by duplex scan before operation, with 34 in the upper leg and 109 in the lower leg, and postoperative ultrasound examination demonstrated that 28 (19.6%) previously refluxing perforator veins persisted, with 2 (5.9%) in the upper leg and 26 (23.9%) in the lower legs. Conclusion: For varicose veins with perforator reflux, superficial vein surgery alone can achieve the goal of relieving symptoms and reducing perforator reflux, while perforator vein surgery may be considered if superficial vein surgery is unsatisfactory.