Takayasu’s arteritis (TA) is a rare chronic vasculitis involving the aorta and its main branches, as well as the pulmonary arteries, and occurs most frequently in women in childbearing age. Currently, the diagnosis for TA active stage depends on systemic manifestations, typical ischemic symptoms, elevated acute-phase responses, and angiographic features. However, the assessment for disease activity and TA-induced damage is insufficient due to its chronic, indolent disease course and lack of specific laboratory and imaging findings. Two recently introduced multi-systemic clinical assessment tools, DEI. Tak and the ITAS 2010, seem to be helpful in assessing the disease activity and damage of TA. How to accurately determine the disease activity, timely detection of disease recurrence and properly define the timing of surgery are still unsolved problems in current clinical practice. In this article, the authors address the issues of these concerns.