Objective: To evaluate the application value of microwave hemostatic device in laparoscopic hepatectomy. Methods: The clinical data of 28 patients undergoing laparoscopic hepatectomy with microwave hemostatic device (HeSetor) from July 2009 to June 2013 were retrospectively analyzed. Results: Laparoscopic hepatectomy was successfully completed in all the 28 patients and no conversion or surgical death occurred. The average operative time was (124±45) min and average intraoperative blood loss was (140±110) mL. No postoperative hemorrhage, bile leakage or liver function failure occurred in the entire group of patients. The mean length of postoperative hospital stay was (6.9±2.7) d. Follow-up was conducted for 6 to 53 months in the 28 patients, and intrahepatic recurrence occurred in 6 cases with hepatocellular carcinoma in postoperative 5–16 months, but no port site tumor implantation was observed. Conclusion: Laparoscopic hepatectomy with microwave hemostatic device can provide excellent hemostatic effect without severe postoperative complications, so it is a safe and feasible technique for liver resection.