Objective: To evaluate feasibility and safety of laparoscopy-assisted proximal gastrectomy in treatment of early-stage proximal gastric cancer. Methods: The clinical data of 72 patients with early-stage proximal gastric cancer undergoing surgical treatment from June 2007 to December 2010 were retrospectively analyzed. Of the patients, 38 cases underwent laparoscopy-assisted proximal gastrectomy (LAPG group) and laparoscopy-assisted subtotal gastrectomy (LAG group). The general conditions, intra- and postoperative variables were compared, and the symptoms of gastroesophageal reflux after surgery between the two groups were also compared by using Visick score. Results: No significant difference was noted in age, gender, body mass index, concomitant disease, operative time and length of postoperative hospital stay between the two groups (all P>0.05), but the intraoperative blood loss in LAPG group was significantly reduced compared with LAG group (P<0.05). The time to first postoperative flatus and food intake, and incidence of early and delayed complications after surgery showed no significant difference between the two groups (all P>0.05), but the postoperative Visick score in LAPG group was significantly higher than that in LAG group (P<0.05). The postoperative pathological parameters, pre- and postoperative changes in nutritional parameters and postoperative survival rate between the two groups showed no significant difference (all P>0.05). Conclusion: laparoscopy-assisted proximal gastrectomy can be safely used in treatment of early proximal gastric cancer and however, the occurrence of postoperative gastroesophageal reflux should be monitored carefully.