Colorectal cancer is one of the most common malignant tumors, with morbidity and mortality exhibiting an increasing trend. Appropriate therapy based on prognosis is an effective approach to reduce the mortality. In recent years, research concerning the prognosis prediction of colorectal cancer has increasingly become a hot-button field, and a lot of potential indicators have been proposed. In this paper, the authors, from the perspectives of histopathology, chromosomes, molecules and genes,describe the prognosis predictor for colorectal cancer.