Hypoparathyroidism (HypoPT) is one of the most common complications after thyroid surgery. It still mainly relies on calcium supplements and activated vitamin D analogues as symptomatic treatment in clinical practice at present, which comes with many problems. Parathyroid hormone replacement therapy (PTH-RT) as a new treatment modality has increasingly been given attention, and has achieved rapid development after continuous efforts for years. The authors present the research progress in PTH-RT from the aspects of drugs for PTH-RT, drug-delivery methods and physical impacts