Objective: To investigate the influence of preoperative ASA classification and scope of surgical operation on the prognosis of gastric cancer after radical operation in patients of different ages. Methods: The clinical data of 188 gastric cancer patients who underwent primary radical resection were retrospectively analyzed. According to the ASA classification, scope of surgical operation and age, the patients were distinguished into high ASA score (score≥3) and low ASA score (score<3) patients, total gastrectomy group and partial gastrectomy patients, and young, middle-aged (<60 years of age) and old-aged (≥60 years of age) patients, respectively. The postoperative survival time between patients grouped by above factors was compared. Results: Survival analysis showed that the postoperative survival time in patients with high ASA score was shorter than that in patients with low ASA score (P<0.05); the postoperative survival time in patients undergoing partial gastrectomy was longer than that in those undergoing total gastrectomy among the young, middle-aged (P<0.05), while there was no significant difference among the old-aged (P>0.05); the postoperative survival time had no significant difference between patients undergoing partial gastrectomy and total gastrectomy among those with high ASA score (P>0.05), but which was longer in the former than that in the latter among those with low ASA score (P<0.05). Conclusion: ASA classification can be used to estimate the prognosis of gastric cancer patients after radical operation. The scope of surgical operation should be strictly controlled in young patients and patients with low preoperative ASA score, and unnecessarily extended operation should be avoided.